The condition is so rare, only a few similar cases have been documented in medical literature. However, some are actually born with very real medical conditions that allow them to claim that they sort of have superpowers. The disorder that causes rapid muscle growth occurs in people who have myostatinrelated muscle hypertrophy, which is a rare genetic condition that reduces body fat and can double the bodys muscle mass. Myostatin function, myostatin disorder and myostatin inhibitor. The condition promotes abovenormal growth of the skeletal muscles. It is caused by a variety of syndromes and diseases, but only a few of them can cause a severe case of it. Myostatinrelated muscle hypertrophy mrmh is a rare genetic disorder with an incomplete autosomal dominant mode of inheritance. Pdf myostatin mutation associated with gross muscle. The source of the disorder within the body is in the mstn gene myostatin gene. Affected individuals have up to twice the usual amount of muscle mass in their bodies.
Causative mutations lead to a loss of myostatin function which results in significant skeletal muscle growth accompanied by loss of subcutaneous fat tissue. An orphanet summary for this disease is currently under development. This condition is not known to cause any medical problems. The father was reportedly also unusually strong, but did not participate in the study.
Liam hoekstra, age three, has super strength, 40% more muscle mass than average children, super speed, and eats a full meal every hour. Its caused by a low amount of myostatin which is a type of protein. This condition is not known to cause any medical problems, and affected individuals are. Myostatin is a member of the transforming growth factor. Childs rare genetic condition causes hulklike super.
For those who are gifted in all these respects their arm measurements will be slightly beyond 18 inches lean and their thigh measurements may except i think 25. His rare genetic condition, myostatinrelated muscle hypertrophy, has no negative health effects. The natural limit to any measurement is based on 1 the chance that you are an above average responder to training 2 height 3 frame size and 4 length of the muscle belly. A grade 11 biology project based on a fictional case study of a young girl possessing a genetic disorder called myostatinrelated muscle hypertrophy myotonic hypertrophy the case study parvati is a star speed skater. Double muscle mutationmyostatin related muscle hypertrophy by gpappas. Super strong kids may hold genetic secrets abc news. Myostatinrelated muscle hypertrophy ncbi bookshelf. Affected individuals have up to twice the usual amount of muscle mass in their bodies and tend to have increased muscle.
Myostatinrelated muscle hypertrophy genetic and rare diseases. Is myostatinrelated muscle hypertrophy possible tiger. The 10 rare diseases and disorders that can turn people. Conclusion myostatinrelated muscle hypertrophy the 10 rare diseases and disorders that can turn people. Myostatinrelated muscle hypertrophy is not known to cause medical problems, and affected individuals are intellectually normal. There are very few cases known related to this disease. The buzz surrounds the idea of inhibiting myostatin either through gene therapy or via germline human genetic modification. Case studies on animals such as mice and cattle have revealed that the muscle growth that results from a lack of myostatin never exceeds 40 percent. Double muscle mutationmyostatinrelated muscle hypertrophy. There is no official method for tracking these conditions.
It happens when body fat reduces and there is an increase in muscle size. Myostatinrelated muscle hypertrophy, or muscle enlargement, is an extremely rare genetic condition. Is myostatinrelated muscle hypertrophy possible tiger fitness. This leads to a condition called myostatinrelated muscle hypertrophy, where people and even children become very muscular and look like bodybuilders without exercising.
There are not many known cases in the realm of this uncommon condition. Brouwers b, riquet j1997a deletion in the bovine myostatin gene causes the. In case of mstn mutation in a human, insertion of 108 basepairs in the mstn gene encoding the propeptide region inhibited cleavage of promstn resulted in. Myostatinrelated muscle hypertrophy or myotonic hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. Soon, the family thought to take him to specialists, who diagnosed liam with a rare condition loosely called myostatinrelated muscle hypertrophy, according to reporting by the ap. The condition, which is also known as muscle hypertrophy syndrome, also can cause increased muscle strength. Clinical manifestations depend on the amount of myostatin. Individuals diagnosed with heterozygous myostatinrelated muscle hypertrophy may have a parent with the mstn mutation who may have increased muscle mass, or the proband may have the condition as the result of a new gene mutation. You can also use our tool to get a more accurate diagnosis based on your current symptoms. Liam hoekstra, a child who was considered to have myostatinrelated muscle hypertrophy at 3 years old, has practically 40% more muscle. Are there any scientifically confirmed cases of humans.
Hanging on rings in an iron cross position by 5 months, pullups by 9 months, liam is the second super baby. However here is one individual case, from 2004, of a 4 and a half year old child. Myostatin mutation associated with gross muscle hypertrophy in a child lawrence g. Myostatinrelated muscle hypertrophy is caused by mutations in the mstn gene. It is caused by deletions in the intron of the mstn gene located on chromosome 2q32.
Due to the extremely low frequency of this disease and diagnosis, it is unknown what percent of babies are born with myostatinrelated muscle hypertrophy in the united states as well as globally. Myostatin mutation associated with gross muscle hypertrophy in a child article pdf available in new england journal of medicine 35026. Myostatinrelated muscle hypertrophy is not known to cause any medical problems, and affected individuals are intellectually normal. Case records of the massachusetts general hospital case.
Myostatinrelated muscle hypertrophy is a rare condition that effects the mstn gene and is characterized by reduced body fat and increased muscle size. At of 2010, there was no clinical treatment for myostatin deficiency. Liam has a rare genetic condition called myostatinrelated muscle hypertrophy, or muscle enlargement. Both heterozygotes and homozygotes for a mutation in mstn encoding the protein growth differentiation factor 8 myostatin can exhibit muscle hypertrophy. In 1997, researchers at johns hopkins university hospital in baltimore determined that belgian blue cattle, an unusually muscular breed, had mutations in the gene that produces myostatin.
A deletion in the bovine myostatin gene causes the doublemuscled phenotype in cattle. Myostatinrelated muscle hypertrophy was first documented in beef cattle and mice in the late 1990s, according to scientific literature. Myostatin mutation associated with gross muscle hypertrophy in a. Myostatinrelated muscle hypertrophy is diagnosed based upon the clinical signs and symptoms in the patient i. Follistatin gene therapy improves ambulation in becker muscular. Probably the most famous case of myostatin related muscle hypetrophy is the one of liam hoekstra, a little boy from michigan, who was able to do expert gymnast moves at only 5 months old. His condition, now known as myostatinrelated muscle hypertrophy, makes him hungry, lean, and strong. These medical conditions are either attained or come by birth. Theres a defect in his genetic code that allows for excessive muscle growth.
However, there are approximately seven known cases of people living with this disease in north america 1. However, other data related to the disease are accessible from the additional information. It is not known how many people are diagnosed with myostatinrelated muscle hypertrophy. Three genetic mutations that can give superhuman abilities. Here you will find a list of rare diseases related to the mstn.
Myostatinrelated muscle hypertrophy is an uncommon condition that outcomes in a decrease of muscle to fat ratio and increment in muscle estimate. It promotes aboveaverage growth of the skeletal muscles without harming the heart or causing. Liam hoekstra, 3, has a rare genetic condition called myostatinrelated muscle hypertrophy, which increases his muscle mass and reduces his. Raisz the new england journal of medicine 1030 n engl j med 351. Pdf lack of myostatin results in excessive muscle growth but. Myostatin is a secreted growth differentiation factor that is a member of the tgf beta protein. The condition is so rare, only a few similar cases have. This is the gene that forms myostatin, which restrains muscle growth. The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has been proposed as a treatment for various muscle wasting disorders. Lack of myostatin results in excessive muscle growth but. Myostatinrelated muscle hypertrophy is a rare condition that results from a mutation in the mstn gene. Unfortunately for the rare diseases, theres often not a calculated incidence or prevalence. Myostatinrelated muscle hypertrophy genetics home reference.
I cant find a follow up on that, but you could make inquiries. Myostatinrelated muscle hypertrophy is characterized by reduced subcutaneous fat pad thickness and increased muscle size in individuals with normal or increased muscle strength. In skeletal muscle, the myostatin precursor, prepromyostatin, is cleaved to promyostatin, which functions to produce an inactive, latent. The genetic diseasecondition that the kid has is called myostatinrelated muscle hypertrophy. This disease has not shown any significant detrimental side effects yet. Enjoy this list of real life medical conditions that could make you a reallife superhero. The reason behind his power is, he was diagnosed with myostatinrelated muscle hypertrophy. Updated photos videos of the myostatin blockade superbaby. Myostatinrelated muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. There have only been 100 cases of this in the world. Rare condition gives toddler super strength ctv news.
Pdf the lack of myostatin promotes growth of skeletal muscle, and. Myostatin also known as growth differentiation factor 8, abbreviated gdf8 is a myokine, a protein produced and released by myocytes that acts on muscle cells autocrine function to inhibit myogenesis. Do you think that super strength can be a curse somehow. Very common between 80% and 100% cases skeletal muscle hypertrophy very common between 80% and 100% cases rare diseases associated to mstn gene.
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